In the pursuit of shedding weight, many individuals may encounter an unexpected side effect: hair loss. Recent studies, including one conducted by researchers at the University of British Columbia, have highlighted a potential link between weight loss medications like Semaglutide (the active ingredient in Wegovy and Ozempic) and hair loss. This post delves into the science behind this connection and explores broader links between weight loss and hair health.

The Semaglutide Study: What We Know

Semaglutide, a GLP-1 receptor agonist, is widely used for weight loss and diabetes management. While its efficacy in promoting weight loss is well-documented, its side effects, including gastrointestinal issues and hair loss, have drawn attention. The University of British Columbia study analyzed data from over 16 million patients and found that Semaglutide users had a 52% higher risk of hair loss compared to users of Contrave, another weight loss medication.

Interestingly, the study revealed that women on Semaglutide were more than twice as likely to experience hair loss compared to women on Contrave. However, the researchers noted limitations, such as the lack of follow-up data on whether hair loss persisted after discontinuing the medication.

Why Does Weight Loss Cause Hair Loss?

Hair loss during weight loss is not exclusive to Semaglutide users. Rapid weight loss, whether through medication, surgery, or extreme fasting, can disrupt the natural hair growth cycle, leading to a condition called Telogen Effluvium. This condition pushes hair follicles into a resting phase, resulting in increased shedding.

Nutrient deficiencies are another culprit. Weight loss often involves reduced calorie intake, which can lead to insufficient levels of essential nutrients like protein, zinc, and biotin—all critical for healthy hair growth. Additionally, the physiological stress of rapid weight loss can exacerbate hair shedding.

The Role of Semaglutide

Semaglutide's appetite-suppressing effects may contribute to nutrient deficiencies, particularly protein, which is vital for hair health. Vomiting, a common side effect of the drug, can further deplete the body of essential nutrients. Some experts also hypothesize that Semaglutide may cause hormonal shifts, increasing the risk of Androgenic Alopecia, a common form of hair loss.

What Can You Do?

If you're considering Semaglutide or any weight loss method, it's essential to weigh the benefits against potential risks like hair loss. Here are some tips to minimize hair loss during weight loss:

• Maintain a Balanced Diet: Ensure your diet includes adequate protein, iron, zinc, and biotin.
• Avoid Rapid Weight Loss: Aim for gradual weight loss to reduce excessive physiological stress.
• Consult a Healthcare Provider: Discuss potential side effects and alternative treatments.

Conclusion

While weight loss can improve overall health, it's crucial to be aware of unintended side effects like hair loss. Medications like Semaglutide offer significant benefits but come with risks that should be carefully considered. By understanding the links between weight loss and hair health, individuals can make informed decisions and take proactive steps to protect their hair and scalp health.

Source: https://www.medrxiv.org/content/10.1101/2025.02.23.25322568v2.full.pdf